Pin-X

Antinematodal Agents

Pyrantel is administered orally.
May administer with food, milk or fruit juice, at any time of day.
Fasting, purgation, or special diets are not necessary for effective treatment.

Shake well before use.
Liquid products can be mixed with milk or fruit juice. Measure liquid products with a calibrated oral dosing device to administer an accurate dosage.

vomiting / Early / Incidence not known
abdominal pain / Early / Incidence not known
nausea / Early / Incidence not known
diarrhea / Early / Incidence not known
dizziness / Early / Incidence not known
headache / Early / Incidence not known

Pin-X, Pronto Plus Pinworm, Reese's

OTC

Oral, anthelmintic agent
Used for roundworm, hookworm, pinworm
Available OTC

11 mg/kg base/dose (Max: 1 g/dose) PO as a single dose; repeat dose in 2 weeks.

11 mg/kg base/dose (Max: 1 g/dose) PO as a single dose; repeat dose in 2 weeks.

11 mg/kg base/dose PO as a single dose; repeat dose in 2 weeks. Consult physician and do not self-treat.

11 mg/kg base/dose PO as a single dose; repeat dose in 2 weeks. Consult physician and do not self-treat.

11 mg/kg base/dose (Max: 1 g/dose) PO once daily for 3 days as an alternative.

11 mg/kg base/dose (Max: 1 g/dose) PO once daily for 3 days as an alternative.

11 mg/kg base/dose (Max: 1 g/dose) PO once daily for 3 days.

11 mg/kg base/dose (Max: 1 g/dose) PO once daily for 3 days.

11 mg/kg base (Max: 1 g) PO as a single dose.

11 mg/kg base (Max: 1 g) PO as a single dose.

†Indicates off-label use

Self-treatment is not recommended.

Specific guidelines for dosage adjustments in renal impairment are not available; it appears that no dosage adjustments are needed.

There are no drug interactions associated with Pyrantel products.

Reese's Oral Susp: 1mL, 144mg

11 mg/kg/dose PO, not to exceed 1 g/dose PO.

11 mg/kg/dose PO, not to exceed 1 g/dose PO.

11 mg/kg/dose PO, not to exceed 1 g/dose PO.

2 years and older: 11 mg/kg/dose PO, not to exceed 1 g/dose PO.
1 year: 11 mg/kg/dose PO has been used off-label.

11 mg/kg/dose PO has been used off-label.

Safety and efficacy have not been established.

By stimulating the release of acetylcholine, inhibiting cholinesterase, and stimulating ganglionic neurons, pyrantel acts as a depolarizing neuromuscular blocking agent in helminths. These actions cause extensive depolarization of the helminth muscle membrane, producing tension of the helminth's muscles, which causes paralysis and release of their hold to the intestinal wall. This action is unlike piperazine, which is a hyperpolarizing neuromuscular blocking agent that relaxes helminth muscles, causing a subsequent detachment from the intestinal wall. Expulsion of the parasites from the GI tract occurs by normal peristalsis.

Pyrantel is administered orally. The absorbed drug is partially metabolized in the liver, with approximately 7% or less of the dose being excreted in urine as unaltered drug and metabolites and more than 50% of each dose being excreted unchanged in the feces.
 
Affected cytochrome P450 isoenzymes and drug transporters: none

Pyrantel has poor and incomplete absorption from the GI tract. Peak plasma concentrations (0.05 to 0.13 mcg/mL) occur within 1 to 3 hours.

Pyrantel is poorly absorbed from the GI tract. There are no well controlled studies of pyrantel use in pregnant women. Use pyrantel with caution during pregnancy. Some experts suggest that single-dose pyrantel therapy may be given to pregnant women. Pregnant women should not take pyrantel unless directed by a doctor.

There are no data regarding the presence of pyrantel in breast milk. Pyrantel is poorly absorbed from the GI tract; therefore, excretion into breast milk may be minimal. Some experts suggest single-dose pyrantel therapy may be given to breast-feeding women. Breast-feeding infant exposure may be minimized if the drug is taken just before the longest sleep interval for the infant.