Fleet

All Other Wound Healing Agents
Emollients and Protectants, Other
Osmotically-Acting Laxatives
Other Agents for Local Oral Treatment
Vaginal Lubricants

Apply gel liberally to cover affected area(s); apply as often as necessary.
If gauze is used as a wound covering, moisten first.
If condition worsens or does not improve within 10 to 14 days, advise patient to consult with their health care provider.

Instruct patient or caregiver on proper use of suppository.
Have the patient lie down on their left side with knees bent and arms resting comfortably or have patient kneel, then lower head and chest forward until left side of face is resting on surface with left arm folded comfortably to provide comfort and support.
Insert suppository well up into rectum. Have patient remain laying to aid in retention of the suppository. The suppository should be retained for at least 15 minutes.
Suppository is designed to dissolve partially, which may not be noticeable. The suppository does not need to melt to produce laxative action
Advise patient to consult their health care provider if using the laxative for longer than 1 week.

bleeding / Early / Incidence not known

ocular irritation / Rapid / Incidence not known

Colace Glycerin, Fleet, Fleet Pedia-Lax, HydroGel, Sani-Supp

OTC

Simple polyol compound that is colorless, odorless, and sweet-tasting
Commonly used rectally as a laxative; used topically to aid in wound management, in ophthalmic products as a lubricating agent for dry eye relief, and as an excipient in pharmacy compounding
Also used as a sweetener in drug products and as a skin moisturizer

2 g suppository rectally every 24 hours as needed.

2 g suppository rectally every 24 hours as needed.

1 g suppository rectally every 24 hours as needed.

Apply liberally to affected area(s) as often as necessary. If gauze is used as a wound covering, moisten first.

Apply liberally to affected area(s) as often as necessary. If gauze is used as a wound covering, moisten first.

Specific guidelines for dosage adjustments in hepatic impairment are not available; it appears that no dosage adjustments are needed.

Specific guidelines for dosage adjustments in renal impairment are not available; it appears that no dosage adjustments are needed.

There are no drug interactions associated with Glycerin products.

Colace Glycerin/Fleet/Fleet Pedia-Lax/Glycerin/Sani-Supp Rectal Supp: 1g, 2g, 2.7mL, 2.8g, 5.4g, 5.4mL, 82.5%
HydroGel Topical Gel: 20%

One 2 gram suppository rectally every 24 hours or as directed by a health care provider

One 2 gram suppository rectally every 24 hours or as directed by a health care provider

One 2 gram suppository rectally every 24 hours or as directed by a health care provider

Children 6 years and older: One 2 gram suppository rectally every 24 hours or as directed by a health care provider
Children 2 to 5 years: One 1 gram suppository rectally every 24 hours or as directed by a health care provider
Children under 2 years: Safety and efficacy have not been established.

Safety and efficacy have not been established.

Safety and efficacy have not been established.

When administered rectally, glycerin is a hyperosmotic laxative. It works in the colon by causing a local irritant effect as well as by drawing water into the intestines softening the stool. Glycerin suppositories usually produce a bowel movement within 15 to 60 minutes after insertion.
 
When administered topically for wound management, glycerin maintains a moist environment and promotes autolytic debridement.

Glycerin is administered rectally for constipation and topically for wound management. The pharmacokinetics of glycerin have not been described by the manufacturer.

Glycerin is found in a variety of food, pharmaceutical, and cosmetic products; use is designated as generally recognized as safe (GRAS). Rectal glycerin nonprescription products for constipation are considered poorly absorbed systemically and use according to product directions for occasional constipation is generally considered acceptable as untoward effects have not been reported. However, other agents may be preferred or more effective during pregnancy. The American Gastroenterological Association recommends PEG 3350 as a first-choice laxative in pregnancy when non-pharmacologic methods (e.g., fluids, dietary fiber) are ineffective or inadequate for preventing or treating constipation. A stool softener such as docusate sodium is also considered low risk.

Glycerin is found in a variety of food, pharmaceutical, and cosmetic products; use is designated as generally recognized as safe (GRAS). Rectal glycerin nonprescription products for constipation are considered poorly absorbed systemically and use according to product directions for occasional constipation is generally considered acceptable during breast-feeding as untoward effects have not been reported.